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Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma

Received: 10 November 2015     Accepted: 19 November 2015     Published: 10 December 2015
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Abstract

We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients.

Published in Journal of Surgery (Volume 3, Issue 6)
DOI 10.11648/j.js.20150306.14
Page(s) 71-76
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Rectal Cancer, Negative LN, Survival

References
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Cite This Article
  • APA Style

    Amir A. Fikry, Niveen A. Abo-Touk. (2015). Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. Journal of Surgery, 3(6), 71-76. https://doi.org/10.11648/j.js.20150306.14

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    ACS Style

    Amir A. Fikry; Niveen A. Abo-Touk. Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. J. Surg. 2015, 3(6), 71-76. doi: 10.11648/j.js.20150306.14

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    AMA Style

    Amir A. Fikry, Niveen A. Abo-Touk. Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. J Surg. 2015;3(6):71-76. doi: 10.11648/j.js.20150306.14

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  • @article{10.11648/j.js.20150306.14,
      author = {Amir A. Fikry and Niveen A. Abo-Touk},
      title = {Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma},
      journal = {Journal of Surgery},
      volume = {3},
      number = {6},
      pages = {71-76},
      doi = {10.11648/j.js.20150306.14},
      url = {https://doi.org/10.11648/j.js.20150306.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150306.14},
      abstract = {We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma
    AU  - Amir A. Fikry
    AU  - Niveen A. Abo-Touk
    Y1  - 2015/12/10
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    N1  - https://doi.org/10.11648/j.js.20150306.14
    DO  - 10.11648/j.js.20150306.14
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 71
    EP  - 76
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20150306.14
    AB  - We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • Departement of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Departement of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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