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Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy

Received: 6 February 2018     Accepted: 24 February 2018     Published: 19 March 2018
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Abstract

Background: Weight loss after laparoscopic sleeve gastrectomy (LSG) is usually attributed to the volume restrictive effect of the procedure in addition to specific hormonal changes. Objective: The present study aimed to investigate the changes in plasma ghrelin levels, the number of ghrelin producing cells and histopathological changes in the remaining pouch after LSG. Methods: The present study included 27 patients with morbid obesity. The plasma ghrelin levels were measured before and six months after LSG and the change in their levels was assessed in relation to body mass index (BMI) after LSG. Immunohistochemical staining of cellular ghrelin was used to evaluate the number and distribution of ghrelin producing cells in the resected specimen and the mucosal changes in the remaining gastric pouch after LSG were assessed at 6 months postoperatively. Results: The mean age of patients was 33.9± 21.9 years. At six months after LSG, BMI decreased from 52.6± 12.8 to 40.8± 7.2 Kg/m2 (p= 0.0001). The plasma ghrelin level decreased significantly from 564.1± 15 to 434.7± 22.6 at six months after LSG. There was strong positive correlation between BMI after LSG and plasma ghrelin level (R= 0.906, p= <0.0001). A significant improvement in the inflammatory parameters was noticed by histopathologic examination. The mean ghrelin positive cell per specimen decreased significantly from 25.37± 3.5 to 13.7 ± 2.12. Conclusion: There was good positive correlation between weight loss and lowering of plasma ghrelin level, also complete removal of the fundus was associated with more weight loss.

Published in Journal of Surgery (Volume 6, Issue 2)
DOI 10.11648/j.js.20180602.12
Page(s) 36-42
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Sleeve Gastrectomy, Mucosal Changes, Ghrelin, Weight Loss

References
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Cite This Article
  • APA Style

    Sabry Ahmed Mahmoud, Ahmed Fadaly Hussein, Waleed Omar, Emad Abdallah, Wagdi Elkashef, et al. (2018). Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy. Journal of Surgery, 6(2), 36-42. https://doi.org/10.11648/j.js.20180602.12

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    ACS Style

    Sabry Ahmed Mahmoud; Ahmed Fadaly Hussein; Waleed Omar; Emad Abdallah; Wagdi Elkashef, et al. Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy. J. Surg. 2018, 6(2), 36-42. doi: 10.11648/j.js.20180602.12

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    AMA Style

    Sabry Ahmed Mahmoud, Ahmed Fadaly Hussein, Waleed Omar, Emad Abdallah, Wagdi Elkashef, et al. Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy. J Surg. 2018;6(2):36-42. doi: 10.11648/j.js.20180602.12

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  • @article{10.11648/j.js.20180602.12,
      author = {Sabry Ahmed Mahmoud and Ahmed Fadaly Hussein and Waleed Omar and Emad Abdallah and Wagdi Elkashef and Mohamed Anwar and Sameh Emile},
      title = {Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy},
      journal = {Journal of Surgery},
      volume = {6},
      number = {2},
      pages = {36-42},
      doi = {10.11648/j.js.20180602.12},
      url = {https://doi.org/10.11648/j.js.20180602.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180602.12},
      abstract = {Background: Weight loss after laparoscopic sleeve gastrectomy (LSG) is usually attributed to the volume restrictive effect of the procedure in addition to specific hormonal changes. Objective: The present study aimed to investigate the changes in plasma ghrelin levels, the number of ghrelin producing cells and histopathological changes in the remaining pouch after LSG. Methods: The present study included 27 patients with morbid obesity. The plasma ghrelin levels were measured before and six months after LSG and the change in their levels was assessed in relation to body mass index (BMI) after LSG. Immunohistochemical staining of cellular ghrelin was used to evaluate the number and distribution of ghrelin producing cells in the resected specimen and the mucosal changes in the remaining gastric pouch after LSG were assessed at 6 months postoperatively. Results: The mean age of patients was 33.9± 21.9 years. At six months after LSG, BMI decreased from 52.6± 12.8 to 40.8± 7.2 Kg/m2 (p= 0.0001). The plasma ghrelin level decreased significantly from 564.1± 15 to 434.7± 22.6 at six months after LSG. There was strong positive correlation between BMI after LSG and plasma ghrelin level (R= 0.906, p= <0.0001). A significant improvement in the inflammatory parameters was noticed by histopathologic examination. The mean ghrelin positive cell per specimen decreased significantly from 25.37± 3.5 to 13.7 ± 2.12. Conclusion: There was good positive correlation between weight loss and lowering of plasma ghrelin level, also complete removal of the fundus was associated with more weight loss.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Gastric Mucosal Changes and Ghrelin Expression and Their Relation to Weight Reduction After Sleeve Gastrectomy
    AU  - Sabry Ahmed Mahmoud
    AU  - Ahmed Fadaly Hussein
    AU  - Waleed Omar
    AU  - Emad Abdallah
    AU  - Wagdi Elkashef
    AU  - Mohamed Anwar
    AU  - Sameh Emile
    Y1  - 2018/03/19
    PY  - 2018
    N1  - https://doi.org/10.11648/j.js.20180602.12
    DO  - 10.11648/j.js.20180602.12
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 36
    EP  - 42
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20180602.12
    AB  - Background: Weight loss after laparoscopic sleeve gastrectomy (LSG) is usually attributed to the volume restrictive effect of the procedure in addition to specific hormonal changes. Objective: The present study aimed to investigate the changes in plasma ghrelin levels, the number of ghrelin producing cells and histopathological changes in the remaining pouch after LSG. Methods: The present study included 27 patients with morbid obesity. The plasma ghrelin levels were measured before and six months after LSG and the change in their levels was assessed in relation to body mass index (BMI) after LSG. Immunohistochemical staining of cellular ghrelin was used to evaluate the number and distribution of ghrelin producing cells in the resected specimen and the mucosal changes in the remaining gastric pouch after LSG were assessed at 6 months postoperatively. Results: The mean age of patients was 33.9± 21.9 years. At six months after LSG, BMI decreased from 52.6± 12.8 to 40.8± 7.2 Kg/m2 (p= 0.0001). The plasma ghrelin level decreased significantly from 564.1± 15 to 434.7± 22.6 at six months after LSG. There was strong positive correlation between BMI after LSG and plasma ghrelin level (R= 0.906, p= <0.0001). A significant improvement in the inflammatory parameters was noticed by histopathologic examination. The mean ghrelin positive cell per specimen decreased significantly from 25.37± 3.5 to 13.7 ± 2.12. Conclusion: There was good positive correlation between weight loss and lowering of plasma ghrelin level, also complete removal of the fundus was associated with more weight loss.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

  • Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

  • General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

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