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Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience

Received: 14 May 2019     Accepted: 23 June 2019     Published: 2 July 2019
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Abstract

Background: Liver regeneration for donors' graft in living donor liver transplantation (LDLT), is an example for liver regeneration in normal liver. In this study we spotted the light on liver regeneration in donors after LDLT, focusing on factors affecting it. Aim: To study the impact of different factors on liver regeneration in donors of living donor liver transplantation. Patients and methods: Between May 2013 and June 2019, 80 living donor liver transplants were performed in the liver transplant unit in EL-Maadi Armed Forces Hospital. All donors who provided liver grafts underwent volumetric spiral computed tomography (CT) scans preoperatively and postoperatively at time intervals of 1 week and 1, 3 and 6 months. Patients’ demographics, surgical data, and postoperative outcomes were correlated with liver regeneration data. 63 patients were males and 17 patients were females, with mean age 27.97yrs ± 5.3. They provided {72} right lobe (RL) grafts and 8 right posterior sector (RP) grafts. Results: No donor operation was aborted and surgical morbidity rate was {33.75%}, mostly biliary. All RP donors achieved complete liver regeneration after 3 months; only four RL donors achieved complete liver regeneration at 6 months. Conclusion: In this study, it was found that there were factors affecting regeneration like age, gender of the patient and graft size. But no effect was found with many factors as peri-operative liver function tests, steatosis, BMI, operative time, blood loss, blood transfusion and postoperative complications.

Published in Journal of Surgery (Volume 7, Issue 4)
DOI 10.11648/j.js.20190704.11
Page(s) 87-95
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Liver Transplantation, Liver Regeneration, Living Donors

References
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Cite This Article
  • APA Style

    Morsi Mohamed, Wael Mansy, Osama Khalil, Yehia Attwa, Magdy Amin, et al. (2019). Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience. Journal of Surgery, 7(4), 87-95. https://doi.org/10.11648/j.js.20190704.11

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    ACS Style

    Morsi Mohamed; Wael Mansy; Osama Khalil; Yehia Attwa; Magdy Amin, et al. Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience. J. Surg. 2019, 7(4), 87-95. doi: 10.11648/j.js.20190704.11

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    AMA Style

    Morsi Mohamed, Wael Mansy, Osama Khalil, Yehia Attwa, Magdy Amin, et al. Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience. J Surg. 2019;7(4):87-95. doi: 10.11648/j.js.20190704.11

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  • @article{10.11648/j.js.20190704.11,
      author = {Morsi Mohamed and Wael Mansy and Osama Khalil and Yehia Attwa and Magdy Amin and Karim Boudjema},
      title = {Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience},
      journal = {Journal of Surgery},
      volume = {7},
      number = {4},
      pages = {87-95},
      doi = {10.11648/j.js.20190704.11},
      url = {https://doi.org/10.11648/j.js.20190704.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20190704.11},
      abstract = {Background: Liver regeneration for donors' graft in living donor liver transplantation (LDLT), is an example for liver regeneration in normal liver. In this study we spotted the light on liver regeneration in donors after LDLT, focusing on factors affecting it. Aim: To study the impact of different factors on liver regeneration in donors of living donor liver transplantation. Patients and methods: Between May 2013 and June 2019, 80 living donor liver transplants were performed in the liver transplant unit in EL-Maadi Armed Forces Hospital. All donors who provided liver grafts underwent volumetric spiral computed tomography (CT) scans preoperatively and postoperatively at time intervals of 1 week and 1, 3 and 6 months. Patients’ demographics, surgical data, and postoperative outcomes were correlated with liver regeneration data. 63 patients were males and 17 patients were females, with mean age 27.97yrs ± 5.3. They provided {72} right lobe (RL) grafts and 8 right posterior sector (RP) grafts. Results: No donor operation was aborted and surgical morbidity rate was {33.75%}, mostly biliary. All RP donors achieved complete liver regeneration after 3 months; only four RL donors achieved complete liver regeneration at 6 months. Conclusion: In this study, it was found that there were factors affecting regeneration like age, gender of the patient and graft size. But no effect was found with many factors as peri-operative liver function tests, steatosis, BMI, operative time, blood loss, blood transfusion and postoperative complications.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Factors Affecting Liver Regeneration in Donors' Grafts in Living Donor Liver Transplant (LDLT) a Center Experience
    AU  - Morsi Mohamed
    AU  - Wael Mansy
    AU  - Osama Khalil
    AU  - Yehia Attwa
    AU  - Magdy Amin
    AU  - Karim Boudjema
    Y1  - 2019/07/02
    PY  - 2019
    N1  - https://doi.org/10.11648/j.js.20190704.11
    DO  - 10.11648/j.js.20190704.11
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 87
    EP  - 95
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20190704.11
    AB  - Background: Liver regeneration for donors' graft in living donor liver transplantation (LDLT), is an example for liver regeneration in normal liver. In this study we spotted the light on liver regeneration in donors after LDLT, focusing on factors affecting it. Aim: To study the impact of different factors on liver regeneration in donors of living donor liver transplantation. Patients and methods: Between May 2013 and June 2019, 80 living donor liver transplants were performed in the liver transplant unit in EL-Maadi Armed Forces Hospital. All donors who provided liver grafts underwent volumetric spiral computed tomography (CT) scans preoperatively and postoperatively at time intervals of 1 week and 1, 3 and 6 months. Patients’ demographics, surgical data, and postoperative outcomes were correlated with liver regeneration data. 63 patients were males and 17 patients were females, with mean age 27.97yrs ± 5.3. They provided {72} right lobe (RL) grafts and 8 right posterior sector (RP) grafts. Results: No donor operation was aborted and surgical morbidity rate was {33.75%}, mostly biliary. All RP donors achieved complete liver regeneration after 3 months; only four RL donors achieved complete liver regeneration at 6 months. Conclusion: In this study, it was found that there were factors affecting regeneration like age, gender of the patient and graft size. But no effect was found with many factors as peri-operative liver function tests, steatosis, BMI, operative time, blood loss, blood transfusion and postoperative complications.
    VL  - 7
    IS  - 4
    ER  - 

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Author Information
  • Hepato-Pancreatico-Biliary Unit, General Surgery Department, Zagazig University, Zagazig, Egypt

  • Hepato-Pancreatico-Biliary Unit, General Surgery Department, Zagazig University, Zagazig, Egypt

  • General Surgery Department, Zagazig University, Zagazig, Egypt

  • Hepato-Pancreatico-Biliary Unit, General Surgery Department, Zagazig University, Zagazig, Egypt

  • Liver Transplant Unit in Hepato-Biliary Department, El-Maadi Armed Forces Hospital, Cairo, Egypt

  • Hepato-Biliary Surgery and Liver Transplant Unit, Rennes University, Rennes, France

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