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Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China

Received: 28 February 2022     Accepted: 15 March 2022     Published: 23 March 2022
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Abstract

Background: The correlation between symptomatic knee osteoarthritis (OA) and whole blood cell count (CBC) has not been well studied based on large-scale population. The purpose of this study was to analyze its correlation with serological examination, especially with CBC tests. Methods: Samples in our study was derived from China Health and Retirement Longitudinal Study (CHARLS), wave 3. Blood samples from 13,420 participants were collected. We define a subject as symptomatic knee OA patient if both questions (Individuals were asked whether they were troubled with knee pain and had a doctor-diagnosed arthritis) were responded positively. A total of 12,952 individuals were classified into four groups. Post hoc multiple comparisons were conducted then. The criterion of significance is p<0.05. Results: Among the 20967 people included in the analysis, 19692 answered the diagnosis questions. Our results showed that the prevalence of symptomatic knee OA was 9.18%. The level of hemoglobin (Hgb) (13.34±1.80 g/dl) in patients with symptomatic knee OA was significantly lower than that in other individuals. The HCT level of symptomatic knee OA individuals (40.53±5.32%) was significantly lower than that of other individuals. Patients with arthritis but without ongoing knee pain had the lowest PLT level (199.09±76.88 × 109/L) when compared with other groups. Conclusion: symptomatic knee osteoarthritis is common in China. Patients with symptomatic knee OA showed a downward trend in the serological results of hemoglobin and hematocrit compared with other populations. More research on symptomatic knee osteoarthritis needs to be carried out.

Published in Journal of Surgery (Volume 10, Issue 2)
DOI 10.11648/j.js.20221002.16
Page(s) 78-82
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Symptomatic Knee Osteoarthritis, Prevalence, Peripheral Blood, Correlation

References
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[2] Long H, Zeng X, Liu Q, et al. Burden of Osteoarthritis in China, 1990 to 2017: Findings from the Global Burden of Disease Study 2017 [J]. The Lancet Rheumatology, 2020, 2 (3). https://doi.org/10.1016/S2665-9913(19)30145-6.
[3] Deshpande BR, Katz JN, Solomon DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity. Arthritis Care Res. 2016; 68: 1743–50. https://doi.org/10.1002/acr.22897.
[4] Tang X, Wang S, Zhan S, et al. The prevalence of symptomatic knee osteoarthritis in China: Results from China Health and Retirement Longitudinal Study [J]. Arthritis & Rheumatology, 2016, 68 (3): 648-653. https://doi.org/10.1002/art.39465.
[5] Biljana S, Anna R, Ewa KW, et al. Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint [J]. Annals of the Rheumatic Diseases, 2018, 77 (2): 300-308. http://dx.doi.org/10.1136/ annrheumdis-2017-211649.
[6] Yang Z, Zhang Z, Lin F, et al. Comparisons of neutrophil-, monocyte-, eosinophil-, and basophil- lymphocyte ratios among various systemic autoimmune rheumatic diseases [J]. APMIS, 2017, 12 5 (10): 863-871. https://doi.org/10.1111/apm.12722.
[7] Chen X, Eileen C, Hu PP, et al. Venous Blood-Based Biomarkers in the China Health and Retirement Longitudinal Study: Rationale, Design, and Results From the 2015 Wave [J]. American Journal of Epidemiology, 2019 (11): 11. https://doi.org/10.1093/aje/kwz170.
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[10] Weber A, Chan PMB, Wen C. Do immune cells lead the way in subchondral bone disturbance in osteoarthritis? [J]. Progress in Biophysics and Molecular Biology, 2019, 148: 21-31. https://doi.org/10.1016/j.pbiomolbio.2017.12.004.
[11] Ishihara Y. Nitroblue tetrazolium tests of blood and synovial fluid cells in rheumatoid arthritis and osteoarthritis (author's transl). [J]. Nihon Seikeigeka Gakkai Zasshi, 1981, 55 (5): 485.
[12] Attur M, Statnikov A, Krasnokutsky S, et al. Elevated peripheral blood leukocyte inflammatory gene expression in radiographic progressors with symptomatic knee osteoarthritis: NYU and OAI cohorts [J]. Osteoarthritis and Cartilage, 2015, 23 (2): A51-A52 https://doi.org/10.1016/j.joca.2015.02.110.
[13] Choi CW, Lee J, Park KH, et al. Incidence of anemia in older Koreans: Community-based cohort study [J]. Archives of Gerontology & Geriatrics, 2005, 41 (3): 303-309. https://doi.org/10.1016/j.archger.2005.04.007.
[14] D Cheyron, Parienti J J, Fekih-Hassen M, et al. Impact of anemia on outcome in critically ill patients with severe acute renal failure [J]. Intensive Care Medicine, 2005, 31 (11): 1529. https://doi.org/10.1007/s00134-005-2739-5.
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  • APA Style

    Tongyi Zhang, Yudian Qiu, Jianhao Lin, Nan Min, Yaonan Zhang, et al. (2022). Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China. Journal of Surgery, 10(2), 78-82. https://doi.org/10.11648/j.js.20221002.16

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    ACS Style

    Tongyi Zhang; Yudian Qiu; Jianhao Lin; Nan Min; Yaonan Zhang, et al. Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China. J. Surg. 2022, 10(2), 78-82. doi: 10.11648/j.js.20221002.16

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    AMA Style

    Tongyi Zhang, Yudian Qiu, Jianhao Lin, Nan Min, Yaonan Zhang, et al. Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China. J Surg. 2022;10(2):78-82. doi: 10.11648/j.js.20221002.16

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  • @article{10.11648/j.js.20221002.16,
      author = {Tongyi Zhang and Yudian Qiu and Jianhao Lin and Nan Min and Yaonan Zhang and Qingyun Xue and Qiang Wang and Liangyuan Wen},
      title = {Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China},
      journal = {Journal of Surgery},
      volume = {10},
      number = {2},
      pages = {78-82},
      doi = {10.11648/j.js.20221002.16},
      url = {https://doi.org/10.11648/j.js.20221002.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221002.16},
      abstract = {Background: The correlation between symptomatic knee osteoarthritis (OA) and whole blood cell count (CBC) has not been well studied based on large-scale population. The purpose of this study was to analyze its correlation with serological examination, especially with CBC tests. Methods: Samples in our study was derived from China Health and Retirement Longitudinal Study (CHARLS), wave 3. Blood samples from 13,420 participants were collected. We define a subject as symptomatic knee OA patient if both questions (Individuals were asked whether they were troubled with knee pain and had a doctor-diagnosed arthritis) were responded positively. A total of 12,952 individuals were classified into four groups. Post hoc multiple comparisons were conducted then. The criterion of significance is pResults: Among the 20967 people included in the analysis, 19692 answered the diagnosis questions. Our results showed that the prevalence of symptomatic knee OA was 9.18%. The level of hemoglobin (Hgb) (13.34±1.80 g/dl) in patients with symptomatic knee OA was significantly lower than that in other individuals. The HCT level of symptomatic knee OA individuals (40.53±5.32%) was significantly lower than that of other individuals. Patients with arthritis but without ongoing knee pain had the lowest PLT level (199.09±76.88 × 109/L) when compared with other groups. Conclusion: symptomatic knee osteoarthritis is common in China. Patients with symptomatic knee OA showed a downward trend in the serological results of hemoglobin and hematocrit compared with other populations. More research on symptomatic knee osteoarthritis needs to be carried out.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Correlation Between Symptomatic Knee Osteoarthritis and Serological Examination: A Longitudinal Study in China
    AU  - Tongyi Zhang
    AU  - Yudian Qiu
    AU  - Jianhao Lin
    AU  - Nan Min
    AU  - Yaonan Zhang
    AU  - Qingyun Xue
    AU  - Qiang Wang
    AU  - Liangyuan Wen
    Y1  - 2022/03/23
    PY  - 2022
    N1  - https://doi.org/10.11648/j.js.20221002.16
    DO  - 10.11648/j.js.20221002.16
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 78
    EP  - 82
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20221002.16
    AB  - Background: The correlation between symptomatic knee osteoarthritis (OA) and whole blood cell count (CBC) has not been well studied based on large-scale population. The purpose of this study was to analyze its correlation with serological examination, especially with CBC tests. Methods: Samples in our study was derived from China Health and Retirement Longitudinal Study (CHARLS), wave 3. Blood samples from 13,420 participants were collected. We define a subject as symptomatic knee OA patient if both questions (Individuals were asked whether they were troubled with knee pain and had a doctor-diagnosed arthritis) were responded positively. A total of 12,952 individuals were classified into four groups. Post hoc multiple comparisons were conducted then. The criterion of significance is pResults: Among the 20967 people included in the analysis, 19692 answered the diagnosis questions. Our results showed that the prevalence of symptomatic knee OA was 9.18%. The level of hemoglobin (Hgb) (13.34±1.80 g/dl) in patients with symptomatic knee OA was significantly lower than that in other individuals. The HCT level of symptomatic knee OA individuals (40.53±5.32%) was significantly lower than that of other individuals. Patients with arthritis but without ongoing knee pain had the lowest PLT level (199.09±76.88 × 109/L) when compared with other groups. Conclusion: symptomatic knee osteoarthritis is common in China. Patients with symptomatic knee OA showed a downward trend in the serological results of hemoglobin and hematocrit compared with other populations. More research on symptomatic knee osteoarthritis needs to be carried out.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Arthritis Clinic and Research Center, Peking University People’s Hospital, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

  • Department of Orthopedic, Beijing Hospital, National Center of Gerontology, Beijing, China

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