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Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA

Received: 9 June 2022     Published: 9 June 2022
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Abstract

Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P < 0.0001), with higher positive expression in squamous cell carcinoma group; TTF-1 was almost not expressed in mediastinal lymph node metastasis from lung squamous cell carcinoma group, so it can effectively distinguish and exclude lymph node metastasis from lung squamous cell carcinoma; Napsin A and CK7 could effectively identify lymph node metastasis from lung adenocarcinoma; Syn, TTF-1, CD56 and CgA were significantly different in lymph node metastasis from small cell lung cancer, of which Syn was the most sensitive (positive expression rate was 90%). Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis.

Published in Journal of Surgery (Volume 10, Issue 3)
DOI 10.11648/j.js.20221003.17
Page(s) 125-130
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA), Lung Cancer, Mediastinal Lymph Node Metastasis, Pathologic Diagnosis, Pathological Classification, Immunohistochemistry

References
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Cite This Article
  • APA Style

    Zhao Congxuan, Yu Tao. (2022). Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA. Journal of Surgery, 10(3), 125-130. https://doi.org/10.11648/j.js.20221003.17

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    ACS Style

    Zhao Congxuan; Yu Tao. Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA. J. Surg. 2022, 10(3), 125-130. doi: 10.11648/j.js.20221003.17

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    AMA Style

    Zhao Congxuan, Yu Tao. Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA. J Surg. 2022;10(3):125-130. doi: 10.11648/j.js.20221003.17

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  • @article{10.11648/j.js.20221003.17,
      author = {Zhao Congxuan and Yu Tao},
      title = {Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA},
      journal = {Journal of Surgery},
      volume = {10},
      number = {3},
      pages = {125-130},
      doi = {10.11648/j.js.20221003.17},
      url = {https://doi.org/10.11648/j.js.20221003.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221003.17},
      abstract = {Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA
    AU  - Zhao Congxuan
    AU  - Yu Tao
    Y1  - 2022/06/09
    PY  - 2022
    N1  - https://doi.org/10.11648/j.js.20221003.17
    DO  - 10.11648/j.js.20221003.17
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 125
    EP  - 130
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20221003.17
    AB  - Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis.
    VL  - 10
    IS  - 3
    ER  - 

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Author Information
  • Department of Ultrasound, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

  • Department of Diagnostic Ultrasound, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China

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